GUARANTEED ABSORPTION. NO NEEDLES, NO PILLS, NO LIVER STRESS!†
Topical vs. Oral Administration
Although comparable to oral-dosage forms in efficacy, topical creams have numerous advantages over oral forms. First, topical administration avoids the first-pass effect of metabolism associated with the oral route. Therefore, topical administration allows for much higher and improved bioavailability. Second, topical administration allows prolonged release of compounds, which can improve adherence. Third, topical administration minimizes adverse effects due to lower peak concentrations of compounds. Most compounds are very effectively removed by the liver when taken orally. This means that much higher doses, ten to twenty times higher, must be taken when administering orally, as compared to topical administration that avoid the first pass effect of the liver.
(Per 8 Pumps)
- 7-Keto® DHEA – 100mg
- 5-DHEA – 50mg
- Phosphatidylserine – 300mg
- Camellia Sinensis – 250mg
Powered by 7-KETO® DHEA
7-Keto-DHEA® is formed from dehydroepiandrosterone (DHEA) in the body. DHEA is a “parent hormone” produced by glands near the kidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen.
7-Keto-DHEA® demonstrates documented thermogenic activity in rats. This is accomplished through the activation of three thermogenic enzymes: Glycerol-3-Phosphate Dehydrogenase, Malic Enzyme and Fatty Acyl CoA Oxidase. In keeping with the biological definition of thermogenesis, all three of these enzyme activations drive energy-producing substrates in a direction of less efficient ATP production relative to heat production. The enzymes also promote the utilization of fat stores for energy and heat production. This is the basis for the ability of 7-keto-DHEA® to enhance thermogenesis and, through that mechanism, accelerate the utilization of fat stores for energy.
A 2007 study demonstrated that administration of 7-Keto-DHEA® to overweight adults in conjunction with a calorie-restricted diet effectively reverses the decline in resting metabolic rate (RMR) normally associated with dieting. 7-Keto-DHEA® demonstrated an ability to increase RMR by 1.4% above baseline levels and demonstrated a 5.4% increase in daily RMR when administered with a calorie-restricted diet. 7-Keto-DHEA® achieves this thermogenic effect without cardiovascular or central nervous system side effects, which are commonly seen with stimulant-associated thermogenic agents.
Clinical Research for 7-Keto® DHEA
A randomized, double-blind, placebo-controlled study of 3-acetyl-7-Keto-dehydroepiandrosterone in healthy overweight adults
The purpose of this study was to determine the effects of 3-acetyl-7-Keto-dehydroepiandrosterone (7-Keto DHEA) in healthy overweight adults.
In a double-blind, placebo-controlled protocol, 30 adults (28 women and 2 men; mean age, 44.5 ± 11.5 years) with a mean body mass index of 31.9 ± 6.2 kg/m2 were randomly divided into 2 groups of 15: Group 1 received 7-oxo-DHEA 100 mg twice daily and Group 2 received placebo for 8 weeks. All subjects participated in an exercise training program 3 times per week. Each exercise session consisted of 60 minutes of cross-training (aerobic and anaerobic exercise) under the supervision of an exercise physiologist. In addition, each subject was instructed to follow a diet of ~1800 kcal/d (20 kcal/[kg · d]) by a registered dietitian. Subjects received biweekly dietary counseling to encourage compliance. Study participants underwent serum multiple-assay chemistry testing, as well as body composition, blood pressure, and dietary analysis at baseline, week 4, and week 8.
Of the 30 subjects who entered the study, 23 completed the 8-week protocol. Seven subjects dropped out for personal reasons unrelated to the study. Group 1 lost a significant amount of body weight compared with Group 2 (−2.88 kg vs −0.97 kg; P = 0.01) over the 8 weeks. Group 1 also achieved a significant reduction in body fat compared with Group 2 (−1.8% vs −0.57%; P = 0.02). The rate of change in body fat per 4-week interval in Group 1 was 3.1 times that in Group 2 (−0.88% vs −0.28%; P < 0.01). Group 1 also experienced a significant increase in triiodothyronine (T3) levels compared with Group 2 over the 8-week study period (+17.88 ng/dL vs 2.75 ng/dL; P = 0.04). There were no significant changes in levels of thyroid-stimulating hormone (TSH) or thyroxine (T4) in either group. In addition, no significant changes were observed in vital signs, blood sugar, testosterone and estradiol levels, liver and renal function, or overall caloric intake during the study. No subjective adverse effects were reported throughout the study.
The results of the study suggest that 7-Keto DHEA combined with moderate exercise and a reduced-calorie diet significantly reduces body weight and body fat compared with exercise and a reduced-calorie diet alone. In addition, 7-Keto DHEA significantly elevated T3 levels but did not affect TSH or T4 levels, indicating that it does not adversely affect thyroid function in the short term.
5-DHEA has been popular in the life extension crowd since the 1980’s. It’s typically used for its ability to support energy and general well being. More recently, higher doses of 5-DHEA have been used to improve body composition due to DHEA’s mild anabolic and thermogenic effects. This makes 5-DHEA an excellent choice for cutting during a calorie deficient diet, since 5-DHEA has good muscle sparing properties.
5-DHEA converts to testosterone at a rate of about 1%, however it has high conversion to 5-androstenediol, where it gets its mild androgenic and anabolic effects. 5-DHEA’s thermogenic properties come from its conversion to 7-Keto DHEA.
Due to 5-DHEA’s mild androgenic effects it rarely produces hair loss or acne. Although 5-DHEA has moderate estrogenic effects, it rarely produces gyno or undesirable estrogenic side effects. Some more sedentary users have reported anxiety or sleeplessness with DHEA, which is likely related to the neurosteroid activity in the brain. However, this effect is also reported as “motivational energy” which is a frequently reported benefit of 5-DHEA.
Andro Shred Topical Delivery System
- Dimethyl Isosorbide (DMI) – is a high purity solvent and carrier which offers a safe, effective delivery enhancement mechanism for the active ingredients in Andro Shred.
- Ethoxydiglycol – is a cosmetic grade solvent that conforms to the current USP/NF monographs. Ethoxydiglycol is particularly appropriate for skin care preparations where it acts as an excellent solvent and carrier.
- Propylene glycol – is an organic compound that is used 2 primary reasons. First, it has the traits of a humectant; it is able to absorb and help the skin retain moisture. Second, it helps active ingredients penetrate the skin.
- Glycerin – when used on skin works as humectant, which is why it attracts moisture onto your skin.
- Carbomer – helps to distribute and suspend the active ingredients in the Andro Shred gel.
- Triethanolamine (TEA) – Helps the water-soluble and oil-soluble ingredients blend better. TEA neutralizes fatty acids and solubilizes oils and other ingredients that are not completely soluble in water.
For best results apply 4 pumps of Andro Shred twice daily (4 pumps in AM & 4 pumps in PM) to the upper arms, shoulders/traps, thighs or abdominal areas. Ensure the areas are clean and free from excessive hair, avoid showering or swimming for at least 8 hours after application.